Important Safety Information
Boxed warning: risk of thyroid C-cell tumors
Semaglutide and tirzepatide caused thyroid C-cell tumors in rodents. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use if you or a family member has had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your clinician right away about a neck lump, hoarseness, trouble swallowing or shortness of breath.
Common side effects
- Nausea, vomiting and diarrhea
- Constipation and stomach pain
- Heartburn, reduced appetite and tiredness
Serious risks
- Pancreatitis (severe, lasting stomach pain)
- Gallbladder problems
- Low blood sugar, especially with insulin or a sulfonylurea
- Kidney problems, often after dehydration
- Serious allergic reactions
Pregnancy
Not for use in pregnancy. Tell your clinician right away if you may be pregnant, are planning a pregnancy or are breastfeeding.
Results vary
Medication is for adults, is used with nutrition and activity, and is prescribed only when a licensed clinician decides it is appropriate. Results vary from person to person, and the examples on this page are illustrative.
Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness or quality. For severe symptoms, seek emergency care. This page describes a fictional sample practice and is not medical advice.