Important Safety Information
WARNING: RISK OF THYROID C-CELL TUMORS. In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). It is not known whether these medications cause MTC in people. Do not use if you or a family member has had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Symptoms of thyroid tumors include a lump or swelling in the neck, trouble swallowing, shortness of breath, or a persistent hoarse voice. Tell your clinician right away if you notice any of these.
Common side effects include nausea, diarrhea, vomiting, constipation, stomach pain and indigestion. Serious side effects can include pancreatitis, gallbladder problems, low blood sugar (especially with insulin or a sulfonylurea), and kidney problems, which can follow dehydration from vomiting or diarrhea. Stop the medication and seek care right away for severe abdominal pain that does not go away.
This medication is not for use during pregnancy. Compounded versions are not FDA-approved. This is not a complete list of risks. Talk with your clinician about your full health history and all of your medications. Results vary, and individual results vary.